MCT Brain Health
Glucose is the primary source of energy for the brain, however, research illustrates that the brain’s sensitivity to glucose levels decreases with age. This phenomenon acts similarly to how diabetics become desensitized to blood glucose levels. Neurologically this event acts almost as ‘diabetes of the brain’.
The lack of glucose utilization by the brain has frequently been linked to neurodegenerative diseases including Alzheimer’s, Parkinson’s, and Dementia. Although the brain cannot utilize glucose, the unrelenting presence of sugar can become neurotoxic and lead to these diseases. 1 Consequently, a ketogenic diet, low in carbohydrates and high in fat and protein, is recommended to supply the brain with the energy it needs. The brain can utilize ketones from a ketogenic diet as an alternative source of energy in place of glucose. 2, 3, 4
Medium-chain triglycerides (MCTs) are a great source of ketone bodies, in addition to a ketogenic diet. The body readily absorbs MCTs into the mitochondria where they are rapidly metabolized to ketone bodies, much different than other types of fat such as LCTs. Thus, individuals whose condition may improve from a ketogenic diet, especially those experiencing or prone to neurodegenerative disease, will benefit from MCT oil consumption. 5, 6
The benefits of a ketogenic diet and ketones were first discovered in children with seizure disorders in the 1920s. Because this diet is often challenging for children, MCT oil is a good source of ketones as it provides calories while allowing a greater variety of foods to be consumed by creating a higher protein and carbohydrate tolerance. 7, 8 A plethora of research has also shown promising results for other medical ailments such as trauma, stroke, neurodegenerative, and malabsoprtion disorders. 9, 10
1 Jockers D. Coconut boosts brain function. 2011. Retrieved from: http://www.naturalnews.com/030971_coconut_brain_function.html
2 Reger MA. Henderson ST, Hale C, Cholerton B, Baker LD, Watson GS, Hyde K, Chapman D, Craft S. Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging. 2004 Mar;25(3):311-4.
3 Kossoff EH, Hartman AL. Ketogenic diets: new advances for metabolism-based therapies. Curr Opin Neurol. 2012 Feb 8
4 Gasior M, Rogawski MA, Hartman AL. Neuroprotective and disease-modifying effects of the ketogenic diet. Behav Pharmacol. 2006 Sep;17(5-6):431-9. Review.
5 Studzinski CM, MacKay WA, Beckett TL, Henderson ST, Murphy MP, Sullivan PG, Burnham WM. Induction of ketosis may improve mitochondrial function and decrease steady-state amyloid-beta precursor protein (APP) levels in the aged dog. Brain Res. 2008 Aug 21;1226:209-17. Epub 2008 Jun 11.
6 Pan Y, Larson B, Araujo JA, Lau W, de Rivera C, Santana R, Gore A, Milgram NW. Dietary supplementation with medium-chain TAG has long-lasting cognition-enhancing effects in aged dogs. Br J Nutr. 2010 Jun;103(12):1746-54. Epub 2010 Feb 9.
7 Liu, Yeou-mei Christiana. Medium-chain triglyceride (MCT) ketogenic therapy. Epilepsia 49 (Suppl. 8) 33-36, 2008
8 Edwards N. The MCT diet. Epilepsy.com. 2007. Retrieved from: http://www.epilepsy.com/epilepsy/keto_news_august07
9 Baranano KW, Hartman AL. The ketogenic diet: uses in epilepsy and other neurologic illnesses. Curr Treat Options Neurol. 2008. Nov;10(6):410-9.
10 Gibson CL, Murphy AN, Murphy SP. Stroke outcome in the ketogenic state—a systematic review of the animal data. J Neurochem. 2012. Nove 123 suppl 2: 52-7.
2 Reger MA. Henderson ST, Hale C, Cholerton B, Baker LD, Watson GS, Hyde K, Chapman D, Craft S. Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging. 2004 Mar;25(3):311-4.
3 Kossoff EH, Hartman AL. Ketogenic diets: new advances for metabolism-based therapies. Curr Opin Neurol. 2012 Feb 8
4 Gasior M, Rogawski MA, Hartman AL. Neuroprotective and disease-modifying effects of the ketogenic diet. Behav Pharmacol. 2006 Sep;17(5-6):431-9. Review.
5 Studzinski CM, MacKay WA, Beckett TL, Henderson ST, Murphy MP, Sullivan PG, Burnham WM. Induction of ketosis may improve mitochondrial function and decrease steady-state amyloid-beta precursor protein (APP) levels in the aged dog. Brain Res. 2008 Aug 21;1226:209-17. Epub 2008 Jun 11.
6 Pan Y, Larson B, Araujo JA, Lau W, de Rivera C, Santana R, Gore A, Milgram NW. Dietary supplementation with medium-chain TAG has long-lasting cognition-enhancing effects in aged dogs. Br J Nutr. 2010 Jun;103(12):1746-54. Epub 2010 Feb 9.
7 Liu, Yeou-mei Christiana. Medium-chain triglyceride (MCT) ketogenic therapy. Epilepsia 49 (Suppl. 8) 33-36, 2008
8 Edwards N. The MCT diet. Epilepsy.com. 2007. Retrieved from: http://www.epilepsy.com/epilepsy/keto_news_august07
9 Baranano KW, Hartman AL. The ketogenic diet: uses in epilepsy and other neurologic illnesses. Curr Treat Options Neurol. 2008. Nov;10(6):410-9.
10 Gibson CL, Murphy AN, Murphy SP. Stroke outcome in the ketogenic state—a systematic review of the animal data. J Neurochem. 2012. Nove 123 suppl 2: 52-7.